GR3000831T3 - Piperazine compounds, process for preparing them, pharmaceutical composition and use - Google Patents

Piperazine compounds, process for preparing them, pharmaceutical composition and use

Info

Publication number
GR3000831T3
GR3000831T3 GR90400162T GR900400162T GR3000831T3 GR 3000831 T3 GR3000831 T3 GR 3000831T3 GR 90400162 T GR90400162 T GR 90400162T GR 900400162 T GR900400162 T GR 900400162T GR 3000831 T3 GR3000831 T3 GR 3000831T3
Authority
GR
Greece
Prior art keywords
preparing
pharmaceutical composition
piperazine compounds
phophylaxis
medicament
Prior art date
Application number
GR90400162T
Other languages
Greek (el)
English (en)
Inventor
Hiroshi Ohtaka
Kenji Yoshida
Kenji Suzuki
Koichi Shimohara
Shigeru Tajima
Keizo Ito
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Publication of GR3000831T3 publication Critical patent/GR3000831T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR90400162T 1986-06-23 1990-08-20 Piperazine compounds, process for preparing them, pharmaceutical composition and use GR3000831T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61147789A JPS632986A (ja) 1986-06-23 1986-06-23 新規なピペラジン誘導体および該化合物を有効成分とする抗潰瘍薬

Publications (1)

Publication Number Publication Date
GR3000831T3 true GR3000831T3 (en) 1991-11-15

Family

ID=15438237

Family Applications (1)

Application Number Title Priority Date Filing Date
GR90400162T GR3000831T3 (en) 1986-06-23 1990-08-20 Piperazine compounds, process for preparing them, pharmaceutical composition and use

Country Status (7)

Country Link
US (1) US4797400A (en])
EP (1) EP0251141B1 (en])
JP (1) JPS632986A (en])
AT (1) ATE53209T1 (en])
DE (1) DE3762969D1 (en])
ES (1) ES2016305B3 (en])
GR (1) GR3000831T3 (en])

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904045D0 (sv) * 1999-11-09 1999-11-09 Astra Ab Compounds
WO2009018413A1 (en) 2007-08-02 2009-02-05 Lubrizol Advanced Materials, Inc. Thermoplastic composition
WO2009091774A1 (en) 2008-01-18 2009-07-23 Lubrizol Advanced Materials, Inc. Thermoplastic composition
KR101718849B1 (ko) 2009-07-07 2017-03-22 루브리졸 어드밴스드 머티어리얼스, 인코포레이티드 열가소성 조성물
CN111093662B (zh) 2017-06-20 2023-10-03 安布里亚制药公司 用于提高心脏代谢效率的组合物和方法
EP4497474A3 (en) 2018-10-17 2025-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2996506A (en) * 1961-08-15 Hcxchb
US2907764A (en) * 1956-07-30 1959-10-06 Searle & Co Heterocyclic esters of 3, 4, 5-trimethoxybenzoic acid
US3025297A (en) * 1959-12-01 1962-03-13 Searle & Co Aminoalkyl esters of 3, 4, 5-trihalobenzoic acids
GB1102011A (en) * 1964-05-21 1968-02-07 Richardson Merrell Spa Phenol esters of amino acids
GB1139934A (en) * 1966-08-18 1969-01-15 Delalande Sa Cinnamylpiperazine preparations
DE1670478A1 (de) * 1967-10-12 1971-02-11 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des alpha-Piperazino-phenylacetonitrils
AT284130B (de) * 1967-12-06 1970-09-10 Asta Werke Ag Chem Fab Verfahren zur Herstellung von neuen, am Kohlenstoff des Heterocyclus alkylierten N,N'-disubstituierten Diazacycloalkanen und deren Säueeadditionssalzen
GB1186495A (en) * 1968-02-20 1970-04-02 Delalande Sa 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation
FR2092630B1 (en]) * 1970-06-03 1974-03-22 Delalande Sa
GB1452413A (en]) * 1973-08-16 1976-10-13 Fuji Chem Ind Co Ltd
US4397855A (en) * 1981-06-26 1983-08-09 Warner-Lambert Company 4-(Substituted)-α, α-dimethyl-1-piperazine pentanoic acids and derivatives as anti-arteriosclerotic agents and method
JPS6113771A (ja) * 1984-06-28 1986-01-22 Saiteku Kk Ｐｌｚｔを用いたラインスキヤナ−

Also Published As

Publication number Publication date
EP0251141A1 (en) 1988-01-07
DE3762969D1 (de) 1990-07-05
US4797400A (en) 1989-01-10
JPH0533952B2 (en]) 1993-05-20
EP0251141B1 (en) 1990-05-30
ES2016305B3 (es) 1990-11-01
JPS632986A (ja) 1988-01-07
ATE53209T1 (de) 1990-06-15

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